First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Frazier Life Sciences Management, L.P.CIK 0001892134 | 7,679,684 | $709.45M | +884,563 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 3,846,530 | $355.34M | +201,244 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 2,414,776 | $223.08M | +2,414,776 | NEW |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 70,000,000 | $209.44M | – | no_change |
FMR LLCCIK 0000315066 | 1,965,375 | $181.56M | +1,318,909 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 1,944,281 | $179.61M | -199,711 | ↓ DEC |
BVF INC/ILCIK 0001056807 | 1,584,727 | $146.40M | +89,437 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 1,432,083 | $132.30M | +1,432,083 | NEW |
TENOR CAPITAL MANAGEMENT Co., L.P.CIK 0001346554 | 43,792,000 | $131.68M | +15,216,000 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 1,408,871 | $130.11M | -684,711 | ↓ DEC |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 1,334,809 | $123.31M | +96,979 | ↑ INC |
Novo Holdings A/SCIK 0001388325 | 1,325,000 | $122.40M | +60,972 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,260,003 | $116.42M | +197,077 | ↑ INC |
TANG CAPITAL MANAGEMENT LLCCIK 0001232621 | 1,236,027 | $114.18M | – | no_change |
CITADEL ADVISORS LLCCIK 0001423053 | 1,063,548 | $98.25M | +210,628 | ↑ INC |
TCG Crossover Management, LLCCIK 0001839948 | 1,062,049 | $98.11M | +1,000,000 | ↑ INC |
BNP PARIBAS FINANCIAL MARKETSCIK 0001166588 | 911,419 | $84.20M | +255,641 | ↑ INC |
READYSTATE ASSET MANAGEMENT LPCIK 0001900923 | 28,000,000 | $83.78M | -2,414,000 | ↓ DEC |
Rock Springs Capital Management LPCIK 0001595725 | 811,294 | $74.95M | +49,000 | ↑ INC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 774,841 | $71.58M | +386,299 | ↑ INC |
Capital World InvestorsCIK 0001422849 | 724,415 | $66.92M | +724,415 | NEW |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 722,177 | $66.71M | +8,725 | ↑ INC |
FRANKLIN RESOURCES INCCIK 0000038777 | 714,804 | $66.03M | +64,089 | ↑ INC |
Clearbridge Investments, LLCCIK 0001348883 | 671,870 | $62.07M | -194,097 | ↓ DEC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 662,306 | $61.18M | -62,011 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
TENOR CAPITAL MANAGEMENT Co., L.P.↑ INC | +15,216,000 | $131.68M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +2,414,776 | $223.08M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +1,432,083 | $132.30M |
FMR LLC↑ INC | +1,318,909 | $181.56M |
TCG Crossover Management, LLC↑ INC | +1,000,000 | $98.11M |
Frazier Life Sciences Management, L.P.↑ INC | +884,563 | $709.45M |
Capital World InvestorsNEW | +724,415 | $66.92M |
Paradigm Biocapital Advisors LPNEW | +625,000 | $57.74M |
TWO SIGMA INVESTMENTS, LP↑ INC | +386,299 | $71.58M |
VANGUARD FIDUCIARY TRUST CONEW | +333,327 | $30.79M |
| Filer | Δ Shares | Value |
|---|---|---|
READYSTATE ASSET MANAGEMENT LP↓ DEC | -2,414,000 | $83.78M |
SSI INVESTMENT MANAGEMENT LLC↓ DEC | -863,000 | $9.71M |
EVENTIDE ASSET MANAGEMENT, LLC↓ DEC | -684,711 | $130.11M |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP↓ DEC | -304,626 | $6.27M |
Nicholas Investment Partners, LP↓ DEC | -300,000 | $5.81M |
STATE STREET CORP↓ DEC | -199,711 | $179.61M |
Clearbridge Investments, LLC↓ DEC | -194,097 | $62.07M |
VOLORIDGE INVESTMENT MANAGEMENT, LLC↓ DEC | -193,851 | $9.62M |
Soleus Capital Management, L.P.↓ DEC | -173,308 | $36.98M |
Pictet Asset Management Holding SA↓ DEC | -153,763 | $39.12M |