First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Frazier Life Sciences Management, L.P.CIK 0001892134 | 4,567,274 | $136.33M | – | no_change |
TRV GP IV, LLCCIK 0001688325 | 4,473,958 | $133.55M | – | no_change |
ARCH Venture Management, LLCCIK 0001274403 | 4,120,053 | $122.98M | – | no_change |
Deep Track Capital, LPCIK 0001856083 | 3,477,562 | $103.81M | -768,878 | ↓ DEC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 2,744,399 | $81.92M | +2,744,399 | NEW |
BlackRock, Inc.CIK 0002012383 | 2,570,425 | $76.73M | +283,270 | ↑ INC |
a16z Capital Management, L.L.C.CIK 0001540358 | 1,702,225 | $50.81M | – | no_change |
Venrock Adviser, LLCCIK 0001615982 | 1,602,034 | $47.82M | +53,465 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,435,656 | $42.85M | +1,435,656 | NEW |
Alphabet Inc.CIK 0001652044 | 1,388,583 | $41.45M | – | no_change |
General Catalyst Group Management, LLCCIK 0001637946 | 1,035,910 | $30.92M | – | no_change |
TRV GP V, LLCCIK 0001990717 | 950,800 | $28.38M | – | no_change |
FMR LLCCIK 0000315066 | 864,214 | $25.80M | +135,609 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 809,214 | $24.16M | +360,997 | ↑ INC |
ArrowMark Colorado Holdings LLCCIK 0001483859 | 767,383 | $22.91M | – | no_change |
Casdin Capital, LLCCIK 0001534261 | 758,857 | $22.65M | – | no_change |
Cormorant Asset Management, LPCIK 0001583977 | 750,000 | $22.39M | +750,000 | NEW |
Woodline Partners LPCIK 0001784547 | 650,229 | $19.41M | -385,000 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 636,722 | $19.01M | +103,717 | ↑ INC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 636,162 | $18.99M | +258,147 | ↑ INC |
Caligan Partners LPCIK 0001727492 | 614,962 | $18.36M | +64,771 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 599,967 | $17.91M | +72,686 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 461,151 | $13.77M | +261,939 | ↑ INC |
Ikarian Capital, LLCCIK 0001778253 | 393,399 | $11.74M | -251,281 | ↓ DEC |
FARALLON CAPITAL MANAGEMENT, L.L.C.CIK 0000909661 | 373,000 | $11.13M | +373,000 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
Paradigm Biocapital Advisors LPNEW | +2,744,399 | $81.92M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,435,656 | $42.85M |
Cormorant Asset Management, LPNEW | +750,000 | $22.39M |
FARALLON CAPITAL MANAGEMENT, L.L.C.NEW | +373,000 | $11.13M |
CITADEL ADVISORS LLC↑ INC | +360,997 | $24.16M |
BlackRock, Inc.↑ INC | +283,270 | $76.73M |
Candriam S.C.A.NEW | +278,167 | $8.30M |
BALYASNY ASSET MANAGEMENT L.P.↑ INC | +261,939 | $13.77M |
DRIEHAUS CAPITAL MANAGEMENT LLC↑ INC | +258,147 | $18.99M |
Aberdeen Group plcNEW | +226,227 | $6.75M |
| Filer | Δ Shares | Value |
|---|---|---|
Deep Track Capital, LP↓ DEC | -768,878 | $103.81M |
MARSHALL WACE, LLP↓ DEC | -536,833 | $9.27M |
Woodline Partners LP↓ DEC | -385,000 | $19.41M |
Foresite Capital Management IV, LLC↓ DEC | -365,756 | $4.68M |
Ikarian Capital, LLC↓ DEC | -251,281 | $11.74M |
Squadron Capital Management LLC↓ DEC | -232,500 | $7.69M |
Parkman Healthcare Partners LLC↓ DEC | -177,422 | $950.54K |
ADAR1 Capital Management, LLC↓ DEC | -129,437 | $1.50M |
BOOTHBAY FUND MANAGEMENT, LLC↓ DEC | -124,896 | $8.49M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -124,578 | $892.28K |