First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Venrock Adviser, LLCCIK 0001615982 | 6,474,485 | $130.33M | -254,500 | ↓ DEC |
Frazier Life Sciences Management, L.P.CIK 0001892134 | 4,961,108 | $99.87M | -78,759 | ↓ DEC |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 4,768,712 | $95.99M | – | no_change |
TANG CAPITAL MANAGEMENT LLCCIK 0001232621 | 4,573,530 | $92.07M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 3,795,897 | $76.41M | +41,749 | ↑ INC |
SILVERARC CAPITAL MANAGEMENT, LLCCIK 0001816307 | 2,876,407 | $57.90M | +449,289 | ↑ INC |
Capital World InvestorsCIK 0001422849 | 2,808,583 | $56.54M | – | no_change |
Caption Management, LLCCIK 0001706766 | 2,430,000 | $48.92M | +2,312,093 | ↑ INC |
Point72 Asset Management, L.P.CIK 0001603466 | 2,136,940 | $43.02M | -146,826 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 1,955,844 | $39.37M | +44,153 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 1,912,146 | $38.49M | -1,008,020 | ↓ DEC |
Vestal Point Capital, LPCIK 0001974915 | 1,850,000 | $37.24M | -40,000 | ↓ DEC |
Parkman Healthcare Partners LLCCIK 0001777015 | 1,835,506 | $36.95M | +66,998 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,830,467 | $36.85M | +1,830,467 | NEW |
Woodline Partners LPCIK 0001784547 | 1,509,920 | $30.39M | -411,172 | ↓ DEC |
Octagon Capital Advisors LPCIK 0001839435 | 1,450,000 | $29.19M | +176,667 | ↑ INC |
Squadron Capital Management LLCCIK 0002050709 | 1,300,100 | $26.17M | +600,100 | ↑ INC |
EMERALD ADVISERS, LLCCIK 0001015083 | 1,264,023 | $25.44M | -76,472 | ↓ DEC |
ARMISTICE CAPITAL, LLCCIK 0001601086 | 1,236,000 | $24.88M | +436,000 | ↑ INC |
Elmind Capital, LPCIK 0002052213 | 1,021,300 | $20.56M | +220,000 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 996,235 | $20.06M | +52,158 | ↑ INC |
Spruce Street Capital LPCIK 0002050194 | 897,681 | $18.07M | +509,713 | ↑ INC |
Freestone Grove Partners LPCIK 0002007591 | 882,906 | $17.77M | +249,887 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 824,293 | $16.59M | -11,011 | ↓ DEC |
EMERALD MUTUAL FUND ADVISERS TRUSTCIK 0001352895 | 805,762 | $16.22M | -49,699 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
Caption Management, LLC↑ INC | +2,312,093 | $48.92M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,830,467 | $36.85M |
Squadron Capital Management LLC↑ INC | +600,100 | $26.17M |
Spruce Street Capital LP↑ INC | +509,713 | $18.07M |
SILVERARC CAPITAL MANAGEMENT, LLC↑ INC | +449,289 | $57.90M |
ARMISTICE CAPITAL, LLC↑ INC | +436,000 | $24.88M |
Catalio Capital Management, LPNEW | +426,551 | $8.59M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +362,900 | $7.31M |
SEB Asset Management ABNEW | +351,305 | $7.07M |
Ishara Investments LPNEW | +276,750 | $5.57M |
| Filer | Δ Shares | Value |
|---|---|---|
MILLENNIUM MANAGEMENT LLC↓ DEC | -1,008,020 | $38.49M |
SCHRODER INVESTMENT MANAGEMENT GROUP↓ DEC | -665,012 | $9.30M |
Woodline Partners LP↓ DEC | -411,172 | $30.39M |
ORBIMED ADVISORS LLC↓ DEC | -288,000 | $1.90M |
MORGAN STANLEY↓ DEC | -261,129 | $8.84M |
Venrock Adviser, LLC↓ DEC | -254,500 | $130.33M |
MARSHALL WACE, LLP↓ DEC | -207,865 | $3.28M |
BARCLAYS PLC↓ DEC | -163,512 | $10.81M |
Point72 Asset Management, L.P.↓ DEC | -146,826 | $43.02M |
Qube Research & Technologies Ltd↓ DEC | -145,121 | $3.63M |