First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Samsara BioCapital, LLCCIK 0001744967 | 5,194,805 | $28.83M | – | no_change |
Caligan Partners LPCIK 0001727492 | 4,974,906 | $27.61M | +2,974,906 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 4,000,000 | $22.20M | – | no_change |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 2,987,613 | $16.58M | +335,043 | ↑ INC |
Trails Edge Capital Partners, LPCIK 0002077247 | 2,657,997 | $14.75M | – | no_change |
FRANKLIN RESOURCES INCCIK 0000038777 | 2,461,565 | $13.66M | -38,576 | ↓ DEC |
SymBiosis Capital Partners, LLCCIK 0002006045 | 2,354,000 | $13.06M | -246,000 | ↓ DEC |
UBS Group AGCIK 0001610520 | 2,318,693 | $12.87M | -325,009 | ↓ DEC |
ADAR1 Capital Management, LLCCIK 0001940272 | 2,174,398 | $12.07M | -535,448 | ↓ DEC |
Andera PartnersCIK 0001757283 | 1,818,181 | $10.09M | – | no_change |
Yu FanCIK 0001668029 | 1,500,000 | $8.32M | – | no_change |
BOOTHBAY FUND MANAGEMENT, LLCCIK 0001549230 | 1,470,407 | $8.16M | +811,436 | ↑ INC |
NEA Management Company, LLCCIK 0001512848 | 1,462,586 | $8.03M | – | no_change |
Ikarian Capital, LLCCIK 0001778253 | 1,429,101 | $7.84M | +926,500 | ↑ INC |
NEXTBio Capital Management LPCIK 0002038158 | 1,333,484 | $7.40M | +34,783 | ↑ INC |
RTW INVESTMENTS, LPCIK 0001493215 | 1,298,702 | $7.21M | +1 | ↑ INC |
Deep Track Capital, LPCIK 0001856083 | 1,222,453 | $6.78M | +732,453 | ↑ INC |
Point72 Asset Management, L.P.CIK 0001603466 | 956,221 | $5.31M | +956,221 | NEW |
AMERIPRISE FINANCIAL INCCIK 0000820027 | 844,215 | $4.69M | +228,742 | ↑ INC |
Ally Bridge Group (NY) LLCCIK 0001822947 | 745,300 | $4.14M | -754,700 | ↓ DEC |
Propel Bio Management, LLCCIK 0001969764 | 724,678 | $3.99M | -275,322 | ↓ DEC |
BVF INC/ILCIK 0001056807 | 686,040 | $3.81M | – | no_change |
MARSHALL WACE, LLPCIK 0001318757 | 654,211 | $3.63M | +482,118 | ↑ INC |
HighVista Strategies LLCCIK 0001335325 | 615,666 | $3.42M | +615,666 | NEW |
MORGAN STANLEYCIK 0000895421 | 613,357 | $3.40M | +105,656 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
Caligan Partners LP↑ INC | +2,974,906 | $27.61M |
Point72 Asset Management, L.P.NEW | +956,221 | $5.31M |
Ikarian Capital, LLC↑ INC | +926,500 | $7.84M |
BOOTHBAY FUND MANAGEMENT, LLC↑ INC | +811,436 | $8.16M |
Deep Track Capital, LP↑ INC | +732,453 | $6.78M |
HighVista Strategies LLCNEW | +615,666 | $3.42M |
MARSHALL WACE, LLP↑ INC | +482,118 | $3.63M |
MILLENNIUM MANAGEMENT LLC↑ INC | +335,043 | $16.58M |
Artisan Partners Limited PartnershipNEW | +323,006 | $1.79M |
Squadron Capital Management LLC↑ INC | +235,000 | $2.97M |
| Filer | Δ Shares | Value |
|---|---|---|
Ally Bridge Group (NY) LLC↓ DEC | -754,700 | $4.14M |
ADAR1 Capital Management, LLC↓ DEC | -535,448 | $12.07M |
J. Goldman & Co LP↓ DEC | -412,927 | $574.52K |
UBS Group AG↓ DEC | -325,009 | $12.87M |
Propel Bio Management, LLC↓ DEC | -275,322 | $3.99M |
SymBiosis Capital Partners, LLC↓ DEC | -246,000 | $13.06M |
GOLDMAN SACHS GROUP INC↓ DEC | -244,688 | $1.03M |
Simplify Asset Management Inc.↓ DEC | -109,739 | $1.26M |
FRANKLIN RESOURCES INC↓ DEC | -38,576 | $13.66M |
Persistent Asset Partners Ltd↓ DEC | -1,612 | $710.95K |