First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
TCG Crossover Management, LLCCIK 0001839948 | 17,754,430 | $39.02M | +17,754,430 | NEW |
Versant Venture Management, LLCCIK 0001560009 | 12,166,109 | $27.50M | +12,166,109 | NEW |
Deep Track Capital, LPCIK 0001856083 | 9,487,745 | $21.44M | +8,944,737 | ↑ INC |
RTW INVESTMENTS, LPCIK 0001493215 | 8,695,652 | $19.65M | +8,695,652 | NEW |
Commodore Capital LPCIK 0001831942 | 8,695,652 | $19.65M | +8,695,652 | NEW |
Venrock Adviser, LLCCIK 0001615982 | 8,695,652 | $19.65M | +6,197,583 | ↑ INC |
Point72 Asset Management, L.P.CIK 0001603466 | 5,964,678 | $13.48M | +3,047 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 5,686,204 | $12.85M | +5,686,204 | NEW |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 5,017,733 | $11.34M | +5,017,733 | NEW |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 4,667,063 | $10.55M | +4,056,676 | ↑ INC |
Spruce Street Capital LPCIK 0002050194 | 4,059,054 | $9.17M | +2,637,522 | ↑ INC |
Woodline Partners LPCIK 0001784547 | 3,043,478 | $6.88M | +2,835,396 | ↑ INC |
Trails Edge Capital Partners, LPCIK 0002077247 | 2,449,993 | $5.54M | +2,449,993 | NEW |
DAFNA Capital Management LLCCIK 0001389933 | 2,434,353 | $5.50M | -359,233 | ↓ DEC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 2,371,430 | $5.36M | +875,514 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 1,524,422 | $3.45M | +922,556 | ↑ INC |
Rock Springs Capital Management LPCIK 0001595725 | 1,304,347 | $2.95M | +1,304,347 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,301,664 | $2.94M | +845,549 | ↑ INC |
Casdin Capital, LLCCIK 0001534261 | 1,228,190 | $2.78M | – | no_change |
Syncona Portfolio LtdCIK 0001725042 | 1,213,056 | $2.74M | – | no_change |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 906,827 | $2.05M | -442,373 | ↓ DEC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 692,963 | $1.57M | +692,963 | NEW |
MARSHALL WACE, LLPCIK 0001318757 | 673,584 | $1.52M | +619,423 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 386,723 | $873.99K | +259,280 | ↑ INC |
NORTHERN TRUST CORPCIK 0000073124 | 230,820 | $521.65K | +125,768 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
TCG Crossover Management, LLCNEW | +17,754,430 | $39.02M |
Versant Venture Management, LLCNEW | +12,166,109 | $27.50M |
Deep Track Capital, LP↑ INC | +8,944,737 | $21.44M |
Commodore Capital LPNEW | +8,695,652 | $19.65M |
RTW INVESTMENTS, LPNEW | +8,695,652 | $19.65M |
Venrock Adviser, LLC↑ INC | +6,197,583 | $19.65M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +5,686,204 | $12.85M |
BALYASNY ASSET MANAGEMENT L.P.NEW | +5,017,733 | $11.34M |
MILLENNIUM MANAGEMENT LLC↑ INC | +4,056,676 | $10.55M |
Woodline Partners LP↑ INC | +2,835,396 | $6.88M |
| Filer | Δ Shares | Value |
|---|---|---|
ACADIAN ASSET MANAGEMENT LLC↓ DEC | -939,028 | $627.00 |
RENAISSANCE TECHNOLOGIES LLC↓ DEC | -442,373 | $2.05M |
DAFNA Capital Management LLC↓ DEC | -359,233 | $5.50M |
SUPERSTRING CAPITAL MANAGEMENT LP↓ DEC | -343,655 | $269.64K |
CITADEL ADVISORS LLC↓ DEC | -306,357 | $29.61K |
GSA CAPITAL PARTNERS LLP↓ DEC | -256,363 | $174.00 |
UBS Group AG↓ DEC | -200,286 | $32.13K |
Squarepoint Ops LLC↓ DEC | -116,549 | $270.08K |
Bank of New York Mellon Corp↓ DEC | -92,632 | $29.15K |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC↓ DEC | -83,962 | $179.48K |