First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Flagship Pioneering, LLCCIK 0001400240 | 62,673,117 | $783.41M | +62,673,117 | NEW |
FMR LLCCIK 0000315066 | 4,217,524 | $52.72M | +4,217,524 | NEW |
Capital World InvestorsCIK 0001422849 | 4,004,149 | $50.05M | +4,004,149 | NEW |
BRAIDWELL LPCIK 0001920938 | 3,592,999 | $44.91M | +3,592,999 | NEW |
JPMORGAN CHASE & COCIK 0000019617 | 2,947,259 | $33.92M | +2,947,259 | NEW |
ARCH Venture Management, LLCCIK 0001274403 | 1,944,426 | $24.31M | +1,944,426 | NEW |
HARBOURVEST PARTNERS LLCCIK 0001201001 | 1,722,210 | $21.53M | +1,722,210 | NEW |
BAKER BROS. ADVISORS LPCIK 0001263508 | 1,423,602 | $17.80M | +1,423,602 | NEW |
HARVARD MANAGEMENT CO INCCIK 0001082621 | 1,111,100 | $13.89M | +1,111,100 | NEW |
NVIDIA CORPCIK 0001045810 | 833,325 | $10.42M | +833,325 | NEW |
Siren, L.L.C.CIK 0002005245 | 736,104 | $9.20M | +736,104 | NEW |
Davern Capital Partners, LPCIK 0002003147 | 591,800 | $7.40M | +591,800 | NEW |
Alyeska Investment Group, L.P.CIK 0001453072 | 500,000 | $6.25M | +500,000 | NEW |
ARK Investment Management LLCCIK 0001697748 | 498,408 | $6.23M | +498,408 | NEW |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 376,893 | $4.71M | +376,893 | NEW |
UBS Group AGCIK 0001610520 | 356,704 | $4.46M | +356,704 | NEW |
Affinity Asset Advisors, LLCCIK 0001773195 | 350,000 | $4.38M | +350,000 | NEW |
MORGAN STANLEYCIK 0000895421 | 337,302 | $4.22M | +337,302 | NEW |
ExodusPoint Capital Management, LPCIK 0001736225 | 311,986 | $3.90M | +311,986 | NEW |
CenterBook Partners LPCIK 0001872738 | 266,813 | $3.34M | +266,813 | NEW |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 185,000 | $2.31M | +185,000 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 170,695 | $2.13M | +170,695 | NEW |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 131,319 | $1.64M | +131,319 | NEW |
SEVEN GRAND MANAGERS, LLCCIK 0001909126 | 125,000 | $1.56M | +125,000 | NEW |
JANE STREET GROUP, LLCCIK 0001595888 | 123,371 | $1.54M | +123,371 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
Flagship Pioneering, LLCNEW | +62,673,117 | $783.41M |
FMR LLCNEW | +4,217,524 | $52.72M |
Capital World InvestorsNEW | +4,004,149 | $50.05M |
BRAIDWELL LPNEW | +3,592,999 | $44.91M |
JPMORGAN CHASE & CONEW | +2,947,259 | $33.92M |
PRICE T ROWE ASSOCIATES INC /MD/NEW | +2,109,633 | $26.37K |
ARCH Venture Management, LLCNEW | +1,944,426 | $24.31M |
HARBOURVEST PARTNERS LLCNEW | +1,722,210 | $21.53M |
BAKER BROS. ADVISORS LPNEW | +1,423,602 | $17.80M |
HARVARD MANAGEMENT CO INCNEW | +1,111,100 | $13.89M |