First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Flagship Pioneering, LLCCIK 0001400240 | 12,674,120 | $60.58M | – | no_change |
FMR LLCCIK 0000315066 | 6,047,198 | $28.91M | +650,384 | ↑ INC |
BVF INC/ILCIK 0001056807 | 5,842,000 | $27.92M | +540,000 | ↑ INC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 4,394,367 | $21.01M | +745,156 | ↑ INC |
RAYMOND JAMES FINANCIAL INCCIK 0000720005 | 2,602,382 | $12.44M | +96,561 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 2,364,866 | $11.30M | +14,996 | ↑ INC |
Euclidean Capital LLCCIK 0001825034 | 1,573,761 | $7.52M | – | no_change |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,495,089 | $7.15M | +1,495,089 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 848,172 | $4.06M | +53,132 | ↑ INC |
Siren, L.L.C.CIK 0002005245 | 720,720 | $3.45M | – | no_change |
STATE STREET CORPCIK 0000093751 | 679,787 | $3.25M | +61,121 | ↑ INC |
AMERIPRISE FINANCIAL INCCIK 0000820027 | 448,976 | $2.15M | -158,694 | ↓ DEC |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 406,425 | $1.94M | +108,689 | ↑ INC |
Candriam S.C.A.CIK 0001537014 | 313,765 | $1.50M | +313,765 | NEW |
JACOBS LEVY EQUITY MANAGEMENT, INCCIK 0000884414 | 303,757 | $1.45M | +34,571 | ↑ INC |
Birchview Capital, LPCIK 0001618205 | 281,730 | $1.35M | – | no_change |
NORTHERN TRUST CORPCIK 0000073124 | 275,875 | $1.32M | +13,445 | ↑ INC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 255,931 | $1.22M | +255,931 | NEW |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 240,586 | $1.15M | +240,586 | NEW |
CITADEL ADVISORS LLCCIK 0001423053 | 200,013 | $956.06K | +17,737 | ↑ INC |
Woodline Partners LPCIK 0001784547 | 180,333 | $861.99K | +158,810 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 136,108 | $650.60K | +17,407 | ↑ INC |
Sio Capital Management, LLCCIK 0001482416 | 122,889 | $587.41K | – | no_change |
PANAGORA ASSET MANAGEMENT INCCIK 0000883677 | 115,063 | $550.00K | +25,768 | ↑ INC |
DAFNA Capital Management LLCCIK 0001389933 | 111,859 | $534.69K | -15,000 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,495,089 | $7.15M |
DEERFIELD MANAGEMENT COMPANY, L.P.↑ INC | +745,156 | $21.01M |
FMR LLC↑ INC | +650,384 | $28.91M |
BVF INC/IL↑ INC | +540,000 | $27.92M |
Candriam S.C.A.NEW | +313,765 | $1.50M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +255,931 | $1.22M |
VANGUARD FIDUCIARY TRUST CONEW | +240,586 | $1.15M |
Woodline Partners LP↑ INC | +158,810 | $861.99K |
RENAISSANCE TECHNOLOGIES LLC↑ INC | +108,689 | $1.94M |
B Group, Inc.NEW | +102,000 | $487.56K |
| Filer | Δ Shares | Value |
|---|---|---|
MILLENNIUM MANAGEMENT LLC↓ DEC | -179,013 | $141.26K |
AMERIPRISE FINANCIAL INC↓ DEC | -158,694 | $2.15M |
Walleye Capital LLC↓ DEC | -46,903 | $164.65K |
BARCLAYS PLC↓ DEC | -43,757 | $92.89K |
Squarepoint Ops LLC↓ DEC | -37,837 | $495.89K |
Point72 Asset Management, L.P.↓ DEC | -34,322 | $132.15K |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↓ DEC | -28,012 | $55.63K |
WELLS FARGO & COMPANY/MN↓ DEC | -24,014 | $70.46K |
MORGAN STANLEY↓ DEC | -23,251 | $470.71K |
DAFNA Capital Management LLC↓ DEC | -15,000 | $534.69K |