Jun 16, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P61,523 $24.9800 $1.54M Jun 15, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P6,146 $24.8900 $152.97K May 20, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P996 $24.9400 $24.84K May 19, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P3,802 $24.9700 $94.94K May 12, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P6,387 $24.9000 $159.04K May 11, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P25,720 $25.0000 $643.00K May 11, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P14,149 $24.4700 $346.23K May 8, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P1,483 $24.9800 $37.05K May 7, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P1,985 $24.9500 $49.52K May 7, 2026 RA CAPITAL MANAGEMENT, L.P. 10% Owner P7,921 $24.3400 $192.80K May 6, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P53,407 $24.8300 $1.33M May 6, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P14,611 $23.7700 $347.30K May 5, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P10,268 $25.0000 $256.70K May 5, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P87,143 $24.5900 $2.14M May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 221,188 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 1,253,384 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 399,212 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 931,502 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 609,840 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 1,422,960 – – May 4, 2026 Novo Holdings A/S 10% Owner C 719,290 $0.0000 $0.00 May 4, 2026 Novo Holdings A/S 10% Owner C 1,366,662 $0.0000 $0.00 May 4, 2026 Novo Holdings A/S 10% Owner C 1,581,052 $0.0000 $0.00 May 4, 2026 Novo Holdings A/S 10% Owner C 513,546 $0.0000 $0.00 May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P133,750 $18.0000 $2.41M May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner P2,541,250 $18.0000 $45.74M May 4, 2026 Novo Holdings A/S 10% Owner C 4,180,550 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 221,188 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 1,009,052 – – May 4, 2026 RA CAPITAL MANAGEMENT, L.P. Director, 10% Owner C 3,607,846 – – May 4, 2026 MARAGANORE JOHN Director C 817 $0.0000 $0.00 May 4, 2026 MARAGANORE JOHN Director C 817 $0.0000 $0.00 May 4, 2026 MARAGANORE JOHN Director C 17,974 – – May 4, 2026 MARAGANORE JOHN Director C 17,974 – – Apr 30, 2026 Behrndt-Eriksen Mads Nikolaj See Remarks A49,016 $0.0000 $0.00 Apr 30, 2026 Madigan Catherine Chief Medical Officer A49,016 $0.0000 $0.00 Jan 29, 2026 Behrndt-Eriksen Mads Nikolaj See Remarks A195,206 $0.0000 $0.00 Jan 29, 2026 Madigan Catherine Chief Medical Officer A145,134 $0.0000 $0.00 Jan 29, 2026 MARAGANORE JOHN Director A107,338 $0.0000 $0.00