First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
TANG CAPITAL MANAGEMENT LLCCIK 0001232621 | 16,790,809 | $88.82M | – | no_change |
ORBIMED ADVISORS LLCCIK 0001055951 | 15,219,994 | $80.51M | – | no_change |
SUVRETTA CAPITAL MANAGEMENT, LLCCIK 0001569064 | 14,307,379 | $75.69M | +125,000 | ↑ INC |
Vivo Capital, LLCCIK 0001674712 | 9,545,466 | $50.50M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 9,506,080 | $50.29M | +117,456 | ↑ INC |
Enavate Sciences GP, LLCCIK 0001953107 | 7,788,150 | $41.20M | – | no_change |
BVF INC/ILCIK 0001056807 | 7,764,842 | $41.08M | – | no_change |
STATE STREET CORPCIK 0000093751 | 6,694,976 | $35.42M | +1,804,451 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 6,037,175 | $31.94M | +6,037,175 | NEW |
RTW INVESTMENTS, LPCIK 0001493215 | 4,186,599 | $22.15M | +1,686,599 | ↑ INC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 3,606,000 | $19.08M | – | no_change |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 3,565,770 | $18.87M | +63,244 | ↑ INC |
Rock Springs Capital Management LPCIK 0001595725 | 3,305,308 | $17.49M | -621,894 | ↓ DEC |
Blue Owl Capital Holdings LPCIK 0001858703 | 2,941,525 | $15.56M | -525,000 | ↓ DEC |
Sofinnova Investments, Inc.CIK 0001631134 | 2,556,161 | $13.52M | -809,285 | ↓ DEC |
Qube Research & Technologies LtdCIK 0001729829 | 2,550,356 | $13.49M | +2,108,551 | ↑ INC |
UBS Group AGCIK 0001610520 | 2,391,333 | $12.65M | +2,223,477 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,995,394 | $10.56M | +477,979 | ↑ INC |
BRAIDWELL LPCIK 0001920938 | 1,965,106 | $10.40M | -821,672 | ↓ DEC |
Blackstone Inc.CIK 0001393818 | 1,857,848 | $9.83M | -4,268,334 | ↓ DEC |
FMR LLCCIK 0000315066 | 1,801,721 | $9.53M | -777,990 | ↓ DEC |
ROYCE & ASSOCIATES LPCIK 0000906304 | 1,619,798 | $8.57M | +1,333,810 | ↑ INC |
AMERIPRISE FINANCIAL INCCIK 0000820027 | 1,596,815 | $8.45M | +773,641 | ↑ INC |
Palo Alto Investors LPCIK 0001306923 | 1,514,504 | $8.01M | -1,017,915 | ↓ DEC |
Birchview Capital, LPCIK 0001618205 | 1,465,867 | $7.75M | -127,071 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +6,037,175 | $31.94M |
UBS Group AG↑ INC | +2,223,477 | $12.65M |
Qube Research & Technologies Ltd↑ INC | +2,108,551 | $13.49M |
STATE STREET CORP↑ INC | +1,804,451 | $35.42M |
RTW INVESTMENTS, LP↑ INC | +1,686,599 | $22.15M |
GREAT POINT PARTNERS LLCNEW | +1,350,000 | $7.14M |
Fisher Asset Management, LLCNEW | +1,348,259 | $7.13M |
ROYCE & ASSOCIATES LP↑ INC | +1,333,810 | $8.57M |
VANGUARD PORTFOLIO MANAGEMENT LLCNEW | +1,082,651 | $5.73M |
VANGUARD FIDUCIARY TRUST CONEW | +998,140 | $5.28M |
| Filer | Δ Shares | Value |
|---|---|---|
Blackstone Inc.↓ DEC | -4,268,334 | $9.83M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -2,263,066 | $4.48M |
Palo Alto Investors LP↓ DEC | -1,017,915 | $8.01M |
BRAIDWELL LP↓ DEC | -821,672 | $10.40M |
Sofinnova Investments, Inc.↓ DEC | -809,285 | $13.52M |
Ikarian Capital, LLC↓ DEC | -782,000 | $95.22K |
FMR LLC↓ DEC | -777,990 | $9.53M |
M&T BANK CORP↓ DEC | -749,186 | $79.58K |
Monashee Investment Management LLC↓ DEC | -741,135 | $1.37M |
Rock Springs Capital Management LP↓ DEC | -621,894 | $17.49M |