First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
MPM BioImpact LLCCIK 0001687078 | 2,593,439 | $17.77M | -78,041 | ↓ DEC |
BRAIDWELL LPCIK 0001920938 | 1,529,675 | $10.48M | +1,529,675 | NEW |
GREAT POINT PARTNERS LLCCIK 0001281446 | 1,334,130 | $9.14M | +354,596 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 1,276,260 | $8.74M | +979,946 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 1,178,659 | $8.07M | +1,178,659 | NEW |
MARSHALL WACE, LLPCIK 0001318757 | 773,123 | $5.30M | +469,108 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 700,000 | $4.79M | -600,000 | ↓ DEC |
SILVERARC CAPITAL MANAGEMENT, LLCCIK 0001816307 | 684,908 | $4.69M | +563,798 | ↑ INC |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 600,946 | $4.12M | – | no_change |
ADAR1 Capital Management, LLCCIK 0001940272 | 597,662 | $4.09M | -834,813 | ↓ DEC |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 459,203 | $3.15M | +13,861 | ↑ INC |
NAN FUNG TRINITY (HK) LtdCIK 0001781880 | 420,517 | $2.88M | -43,137 | ↓ DEC |
SPHERA FUNDS MANAGEMENT LTD.CIK 0001496201 | 419,247 | $2.87M | -513,000 | ↓ DEC |
BlackRock, Inc.CIK 0002012383 | 401,649 | $2.75M | +12,340 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 345,663 | $2.37M | +106,620 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 312,999 | $2.15M | +2,243 | ↑ INC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 310,606 | $2.13M | -256,106 | ↓ DEC |
DIADEMA PARTNERS LPCIK 0002026172 | 286,126 | $1.96M | +149,638 | ↑ INC |
TD ASSET MANAGEMENT INCCIK 0001056053 | 250,102 | $1.71M | +3,902 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 234,182 | $1.60M | +85,644 | ↑ INC |
Longaeva Partners L.P.CIK 0002054122 | 217,768 | $1.49M | +217,768 | NEW |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 217,300 | $1.49M | -103,300 | ↓ DEC |
SUPERSTRING CAPITAL MANAGEMENT LPCIK 0001931118 | 199,209 | $1.36M | +101,049 | ↑ INC |
JANE STREET GROUP, LLCCIK 0001595888 | 185,975 | $1.27M | -1,428 | ↓ DEC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 158,660 | $1.09M | +158,660 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
BRAIDWELL LPNEW | +1,529,675 | $10.48M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +1,178,659 | $8.07M |
MILLENNIUM MANAGEMENT LLC↑ INC | +979,946 | $8.74M |
SILVERARC CAPITAL MANAGEMENT, LLC↑ INC | +563,798 | $4.69M |
MARSHALL WACE, LLP↑ INC | +469,108 | $5.30M |
GREAT POINT PARTNERS LLC↑ INC | +354,596 | $9.14M |
Longaeva Partners L.P.NEW | +217,768 | $1.49M |
VANGUARD FIDUCIARY TRUST CONEW | +158,660 | $1.09M |
DIADEMA PARTNERS LP↑ INC | +149,638 | $1.96M |
Verdad Advisers, LPNEW | +144,540 | $990.10K |
| Filer | Δ Shares | Value |
|---|---|---|
ADAR1 Capital Management, LLC↓ DEC | -834,813 | $4.09M |
Point72 Asset Management, L.P.↓ DEC | -657,590 | $404.77K |
Affinity Asset Advisors, LLC↓ DEC | -600,000 | $4.79M |
CANTOR FITZGERALD, L. P.↓ DEC | -517,173 | $205.50K |
SPHERA FUNDS MANAGEMENT LTD.↓ DEC | -513,000 | $2.87M |
Peapod Lane Capital LLC↓ DEC | -457,114 | $739.80K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -256,106 | $2.13M |
683 Capital Management, LLC↓ DEC | -111,652 | $616.50K |
RENAISSANCE TECHNOLOGIES LLC↓ DEC | -103,300 | $1.49M |
MPM BioImpact LLC↓ DEC | -78,041 | $17.77M |