| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 17, 2026 | De Vre Raymond | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | DILLY STEPHEN GEORGE | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | Martinborough Esther | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | Singhvi Rahul | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | Smith David V | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | Collins Cynthia | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | Richards Christos | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 17, 2026 | PARKER H STEWART | Director | A | 66,350 | $0.0000 | $0.00 |
| Jun 11, 2026 | De Vre Raymond | Director | S | 2,605 | $2.3700 | $6.17K |
| Feb 24, 2026 | Lutz Stefan | Chief Scientific Officer | S | 5,862 | $1.1329 | $6.64K |
| Feb 23, 2026 | Erbez Georgia | See Remarks | A | 316,100 | $0.0000 | $0.00 |
| Feb 23, 2026 | MOORE ALISON | President and CEO | A | 993,000 | $0.0000 | $0.00 |
| Feb 23, 2026 | Lutz Stefan | Chief Scientific Officer | A | 316,100 | $0.0000 | $0.00 |
| Feb 6, 2026 | MOORE ALISON | President and CEO | S | 3,826 | $1.3071 | $5.00K |
| Feb 6, 2026 | Lutz Stefan | Chief Scientific Officer | S | 2,492 | $1.3071 | $3.26K |
| Feb 6, 2026 | Erbez Georgia | See Remarks | S | 3,826 | $1.3071 | $5.00K |
| Jan 7, 2026 | Lutz Stefan | CSO | S | 4,685 | $1.6968 | $7.95K |
| Dec 1, 2025 | Opaleye Management Inc. | 10% Owner | S | 8,533 | $1.6675 | $14.23K |
| Dec 1, 2025 | Opaleye Management Inc. | 10% Owner | S | 245,000 | $1.6675 | $408.54K |
| Dec 1, 2025 | Opaleye Management Inc. | 10% Owner | S | 8,533 | $1.6675 | $14.23K |
| Dec 1, 2025 | Opaleye Management Inc. | 10% Owner | S | 245,000 | $1.6675 | $408.54K |
| Nov 28, 2025 | Opaleye Management Inc. | 10% Owner | S | 2,490 | $1.7500 | $4.36K |
| Nov 28, 2025 | Opaleye Management Inc. | 10% Owner | S | 105,000 | $1.7500 | $183.75K |
| Nov 28, 2025 | Opaleye Management Inc. | 10% Owner | S | 2,490 | $1.7500 | $4.36K |
| Nov 28, 2025 | Opaleye Management Inc. | 10% Owner | S | 105,000 | $1.7500 | $183.75K |
| Nov 26, 2025 | Opaleye Management Inc. | 10% Owner | S | 5,000 | $1.7413 | $8.71K |
| Nov 26, 2025 | Opaleye Management Inc. | 10% Owner | S | 148,318 | $1.7413 | $258.27K |
| Nov 26, 2025 | Opaleye Management Inc. | 10% Owner | S | 5,000 | $1.7413 | $8.71K |
| Nov 26, 2025 | Opaleye Management Inc. | 10% Owner | S | 148,318 | $1.7413 | $258.27K |
| Nov 21, 2025 | WOLF DENNIS P | Director | S | 8,952 | $1.5626 | $13.99K |
| Nov 13, 2025 | MOORE ALISON | President and CEO | A | 500,000 | $0.0000 | $0.00 |
| Nov 13, 2025 | MOORE ALISON | President and CEO | A | 85,000 | $0.0000 | $0.00 |
| Nov 12, 2025 | Opaleye Management Inc. | 10% Owner | S | 165,000 | $1.9620 | $323.73K |
| Nov 12, 2025 | Opaleye Management Inc. | 10% Owner | S | 27,459 | $1.9372 | $53.19K |
| Nov 12, 2025 | Opaleye Management Inc. | 10% Owner | S | 890,000 | $1.9372 | $1.72M |
| Nov 11, 2025 | Opaleye Management Inc. | 10% Owner | S | 13,211 | $1.7994 | $23.77K |
| Nov 11, 2025 | Opaleye Management Inc. | 10% Owner | S | 535,000 | $1.7994 | $962.68K |
| Nov 11, 2025 | DILLY STEPHEN GEORGE | Director | A | 50,000 | $1.8473 | $92.36K |
| Nov 11, 2025 | De Vre Raymond | Director | S | 1,413 | $1.7400 | $2.46K |
| Nov 11, 2025 | Opaleye Management Inc. | 10% Owner | S | 13,211 | $1.7994 | $23.77K |
| Nov 11, 2025 | Opaleye Management Inc. | 10% Owner | S | 535,000 | $1.7994 | $962.68K |
| Nov 10, 2025 | Opaleye Management Inc. | 10% Owner | S | 3,318 | $1.7347 | $5.75K |
| Nov 10, 2025 | Opaleye Management Inc. | 10% Owner | S | 205,000 | $1.7347 | $355.61K |
| Nov 10, 2025 | Opaleye Management Inc. | 10% Owner | S | 3,318 | $1.7347 | $5.75K |
| Nov 10, 2025 | Opaleye Management Inc. | 10% Owner | S | 205,000 | $1.7347 | $355.61K |
| Nov 7, 2025 | Opaleye Management Inc. | 10% Owner | S | 10,000 | $1.6968 | $16.97K |
| Nov 7, 2025 | Opaleye Management Inc. | 10% Owner | S | 296,682 | $1.6968 | $503.41K |
| Nov 7, 2025 | Opaleye Management Inc. | 10% Owner | S | 10,000 | $1.6968 | $16.97K |
| Nov 7, 2025 | Opaleye Management Inc. | 10% Owner | S | 296,682 | $1.6968 | $503.41K |
| Oct 13, 2025 | MOORE ALISON | Chief Technical Officer | S | 6,239 | $2.5051 | $15.63K |