| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 22, 2026 | McNeill Jonathan | President and COO | S | 20,549 | $17.9900 | $369.68K |
| Jun 22, 2026 | Brumm Joshua T | Chief Executive Officer | S | 42,305 | $17.9900 | $761.07K |
| Jun 22, 2026 | Im Ellie Eunkyung | Chief Medical Officer | S | 1,219 | $17.9900 | $21.93K |
| Jun 22, 2026 | Bispham Barbara Harlin | See Remarks | S | 1,218 | $17.9900 | $21.91K |
| Jun 22, 2026 | Scalzo Richard William | Chief Financial Officer | S | 1,112 | $17.9900 | $20.00K |
| Jun 22, 2026 | Pinkas Jan | Chief Scientific Officer | S | 1,288 | $17.9900 | $23.17K |
| Jun 22, 2026 | Lynch Ryan | See Remarks | S | 465 | $17.9900 | $8.37K |
| Jun 2, 2026 | Fairmount Funds Management LLC | Director, 10% Owner | A | 11,050 | $0.0000 | $0.00 |
| Jun 2, 2026 | Moran Susan | Director | A | 11,050 | $0.0000 | $0.00 |
| Jun 2, 2026 | Balcom Alexandra | Director | A | 11,050 | $0.0000 | $0.00 |
| Jun 2, 2026 | Lubner David Charles | Director | A | 11,050 | $0.0000 | $0.00 |
| Jun 2, 2026 | Violin Jonathan | Director | A | 11,050 | $0.0000 | $0.00 |
| Dec 15, 2025 | Bispham Barbara Harlin | See Remarks | A | 72,185 | $0.0000 | $0.00 |
| Dec 15, 2025 | Bispham Barbara Harlin | See Remarks | A | 6,000 | – | – |
| Dec 15, 2025 | Bispham Barbara Harlin | See Remarks | A | 12,422 | – | – |
| Dec 15, 2025 | Lynch Ryan | See Remarks | A | 33,512 | $0.0000 | $0.00 |
| Dec 15, 2025 | Lynch Ryan | See Remarks | A | 4,000 | – | – |
| Dec 15, 2025 | Lynch Ryan | See Remarks | A | 8,378 | – | – |
| Dec 15, 2025 | Im Ellie Eunkyung | Chief Medical Officer | A | 65,190 | $0.0000 | $0.00 |
| Dec 15, 2025 | Im Ellie Eunkyung | Chief Medical Officer | A | 5,000 | – | – |
| Dec 15, 2025 | Im Ellie Eunkyung | Chief Medical Officer | A | 16,298 | – | – |
| Dec 15, 2025 | McNeill Jonathan | President and COO | A | 78,029 | $0.0000 | $0.00 |
| Dec 15, 2025 | McNeill Jonathan | President and COO | A | 6,000 | – | – |
| Dec 15, 2025 | McNeill Jonathan | President and COO | A | 19,507 | – | – |
| Dec 15, 2025 | Scalzo Richard William | Chief Financial Officer | A | 57,688 | $0.0000 | $0.00 |
| Dec 15, 2025 | Scalzo Richard William | Chief Financial Officer | A | 5,000 | – | – |
| Dec 15, 2025 | Scalzo Richard William | Chief Financial Officer | A | 14,422 | – | – |
| Dec 15, 2025 | Brumm Joshua T | Chief Executive Officer | A | 180,467 | $0.0000 | $0.00 |
| Dec 15, 2025 | Brumm Joshua T | Chief Executive Officer | A | 10,000 | – | – |
| Dec 15, 2025 | Brumm Joshua T | Chief Executive Officer | A | 45,117 | – | – |
| Dec 15, 2025 | Doughty Christopher Grant | Chief Business Officer | A | 58,855 | $0.0000 | $0.00 |
| Dec 15, 2025 | Doughty Christopher Grant | Chief Business Officer | A | 8,000 | – | – |
| Dec 15, 2025 | Doughty Christopher Grant | Chief Business Officer | A | 14,714 | – | – |
| Dec 15, 2025 | Pinkas Jan | Chief Scientific Officer | A | 70,025 | $0.0000 | $0.00 |
| Dec 15, 2025 | Pinkas Jan | Chief Scientific Officer | A | 5,000 | – | – |
| Dec 15, 2025 | Pinkas Jan | Chief Scientific Officer | A | 17,507 | – | – |
| Dec 8, 2025 | Brumm Joshua T | Chief Executive Officer | A | 345,672 | $0.0000 | $0.00 |
| Dec 8, 2025 | McNeill Jonathan | President and COO | A | 172,836 | $0.0000 | $0.00 |
| Dec 4, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | P | 131,434 | $13.4090 | $1.76M |
| Dec 4, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | P | 1,360,000 | $13.4100 | $18.24M |
| Jul 16, 2025 | Pinkas Jan | Chief Scientific Officer | A | 142,474 | $0.0000 | $0.00 |
| Jun 23, 2025 | Lubner David Charles | Director | A | 9,023 | $0.0000 | $0.00 |
| Jun 23, 2025 | Balcom Alexandra | Director | A | 9,023 | $0.0000 | $0.00 |
| Jun 23, 2025 | Violin Jonathan | Director | A | 9,023 | $0.0000 | $0.00 |
| Jun 23, 2025 | Fairmount Funds Management LLC | Director, 10% Owner | A | 9,023 | $0.0000 | $0.00 |
| Jun 23, 2025 | Moran Susan | Director | A | 9,023 | $0.0000 | $0.00 |
| Jun 13, 2025 | BVF PARTNERS L P/IL | 10% Owner | J | 25,944 | – | – |
| Jun 13, 2025 | BVF PARTNERS L P/IL | 10% Owner | J | 257,515 | – | – |
| Jun 13, 2025 | BVF PARTNERS L P/IL | 10% Owner | J | 304,098 | – | – |
| Jun 13, 2025 | BVF PARTNERS L P/IL | 10% Owner | J | 56,079 | – | – |