First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
TCG Crossover Management, LLCCIK 0001839948 | 7,915,567 | $33.01M | +7,915,567 | NEW |
Commodore Capital LPCIK 0001831942 | 6,336,782 | $26.42M | +2,986,782 | ↑ INC |
Avidity Partners Management LPCIK 0001791827 | 6,049,999 | $23.59M | +2,839,266 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 5,348,561 | $22.30M | +788,584 | ↑ INC |
Opaleye Management Inc.CIK 0001595855 | 4,675,000 | $19.49M | +3,490,500 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 4,378,956 | $18.26M | +4,378,956 | NEW |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 4,046,640 | $16.87M | +2,640,266 | ↑ INC |
CITADEL ADVISORS LLCCIK 0001423053 | 3,640,204 | $15.18M | +3,314,713 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 3,164,582 | $13.20M | +2,864,582 | ↑ INC |
STATE STREET CORPCIK 0000093751 | 3,132,670 | $13.06M | +1,991,423 | ↑ INC |
BALYASNY ASSET MANAGEMENT L.P.CIK 0001218710 | 2,994,460 | $12.49M | +2,863,546 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 2,983,342 | $12.44M | -1,491,180 | ↓ DEC |
Spruce Street Capital LPCIK 0002050194 | 2,627,107 | $10.96M | +2,627,107 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 1,766,960 | $7.37M | +352,438 | ↑ INC |
Patient Square Capital LPCIK 0001819257 | 1,625,000 | $6.78M | +492,185 | ↑ INC |
Nicholson Wealth Management Group, LLCCIK 0002035982 | 1,618,993 | $6.75M | +1,000 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 1,241,816 | $5.18M | +1,081,979 | ↑ INC |
Yu FanCIK 0001668029 | 1,055,409 | $4.40M | +1,055,409 | NEW |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 1,003,474 | $4.18M | -195,170 | ↓ DEC |
Ally Bridge Group (NY) LLCCIK 0001822947 | 926,557 | $3.86M | +584,818 | ↑ INC |
Nuveen, LLCCIK 0001871926 | 910,221 | $3.80M | -363,786 | ↓ DEC |
Hills Bank & Trust CoCIK 0001309148 | 872,200 | $3.64M | -66,000 | ↓ DEC |
Octagon Capital Advisors LPCIK 0001839435 | 791,555 | $3.30M | -2,226,445 | ↓ DEC |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 752,033 | $3.14M | +752,033 | NEW |
ADAR1 Capital Management, LLCCIK 0001940272 | 749,335 | $3.12M | +654,142 | ↑ INC |
| Filer | Δ Shares | Value |
|---|---|---|
TCG Crossover Management, LLCNEW | +7,915,567 | $33.01M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +4,378,956 | $18.26M |
Opaleye Management Inc.↑ INC | +3,490,500 | $19.49M |
CITADEL ADVISORS LLC↑ INC | +3,314,713 | $15.18M |
Commodore Capital LP↑ INC | +2,986,782 | $26.42M |
Affinity Asset Advisors, LLC↑ INC | +2,864,582 | $13.20M |
BALYASNY ASSET MANAGEMENT L.P.↑ INC | +2,863,546 | $12.49M |
Avidity Partners Management LP↑ INC | +2,839,266 | $23.59M |
MILLENNIUM MANAGEMENT LLC↑ INC | +2,640,266 | $16.87M |
Spruce Street Capital LPNEW | +2,627,107 | $10.96M |
| Filer | Δ Shares | Value |
|---|---|---|
Octagon Capital Advisors LP↓ DEC | -2,226,445 | $3.30M |
MORGAN STANLEY↓ DEC | -1,491,180 | $12.44M |
ExodusPoint Capital Management, LP↓ DEC | -464,563 | $488.10K |
UBS Group AG↓ DEC | -405,426 | $2.17M |
Nuveen, LLC↓ DEC | -363,786 | $3.80M |
TWO SIGMA INVESTMENTS, LP↓ DEC | -195,170 | $4.18M |
JANE STREET GROUP, LLC↓ DEC | -193,595 | $411.58K |
BANK OF AMERICA CORP /DE/↓ DEC | -182,595 | $1.01M |
BARCLAYS PLC↓ DEC | -77,742 | $62.75K |
Mariner, LLC↓ DEC | -74,301 | $49.26K |