| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 10, 2026 | Nashat Amir | Director, 10% Owner | A | 28,000 | $0.0000 | $0.00 |
| Jun 10, 2026 | Stewart Murray | Director | A | 28,000 | $0.0000 | $0.00 |
| Jun 10, 2026 | Holtzman Steven H | Director | A | 28,000 | $0.0000 | $0.00 |
| Jun 10, 2026 | Schwab Andrew J. | Director, 10% Owner | A | 28,000 | $0.0000 | $0.00 |
| Jun 10, 2026 | Young Richard A | Director | A | 28,000 | $0.0000 | $0.00 |
| Jun 10, 2026 | WILLIAMS DOUGLAS E | Director | A | 28,000 | $0.0000 | $0.00 |
| Apr 1, 2026 | MacLean Michael F | Director | A | 56,000 | $0.0000 | $0.00 |
| Apr 1, 2026 | Mandel-Brehm Josh | Chief Executive Officer | A | 580,000 | $0.0000 | $0.00 |
| Apr 1, 2026 | Gold Kelly | Chief Financial Officer | A | 215,000 | $0.0000 | $0.00 |
| Apr 1, 2026 | Maricich Yuri | Chief Medical Officer | A | 215,000 | $0.0000 | $0.00 |
| Apr 1, 2026 | Tardiff Daniel | Chief Scientific Officer | A | 170,000 | $0.0000 | $0.00 |
| Dec 11, 2025 | Mandel-Brehm Josh | Chief Executive Officer | A | 425,000 | $0.0000 | $0.00 |
| Dec 11, 2025 | Gold Kelly | Chief Financial Officer | A | 190,000 | $0.0000 | $0.00 |
| Dec 11, 2025 | Maricich Yuri | Chief Medical Officer | A | 190,000 | $0.0000 | $0.00 |
| Dec 11, 2025 | Tardiff Daniel | Chief Scientific Officer | A | 145,500 | $0.0000 | $0.00 |
| Sep 11, 2025 | Young Richard A | Director | P | 15,151 | $1.6500 | $25.00K |
| Sep 11, 2025 | Mandel-Brehm Josh | Chief Executive Officer | P | 6,060 | $1.6500 | $10.00K |
| Sep 11, 2025 | Gold Kelly | Chief Financial Officer | P | 6,060 | $1.6500 | $10.00K |
| Sep 11, 2025 | Maricich Yuri | Chief Medical Officer | P | 6,060 | $1.6500 | $10.00K |
| Sep 11, 2025 | Nashat Amir | Director, 10% Owner | P | 85,468 | $1.5300 | $130.77K |
| Sep 11, 2025 | Nashat Amir | Director, 10% Owner | P | 1,221,721 | $1.5300 | $1.87M |
| Sep 11, 2025 | Polaris Management Co. VII, L.L.C. | 10% Owner | P | 85,468 | $1.5300 | $130.77K |
| Sep 11, 2025 | Polaris Management Co. VII, L.L.C. | 10% Owner | P | 1,221,721 | $1.5300 | $1.87M |
| Sep 11, 2025 | 5AM Partners VI, LLC | 10% Owner | P | 2,941,176 | $1.5300 | $4.50M |
| Sep 11, 2025 | Schwab Andrew J. | Director, 10% Owner | A | 2,941,176 | $1.5300 | $4.50M |
| Jun 25, 2025 | Ragan Paula | Director | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Thadhani Ravi I. | Director | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Holtzman Steven H | Director | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Nashat Amir | Director, 10% Owner | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Schwab Andrew J. | Director, 10% Owner | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Boylan James P | Director | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Higgins Michael J | Director | A | 9,000 | $0.0000 | $0.00 |
| Jun 25, 2025 | Young Richard A | Director | A | 9,000 | $0.0000 | $0.00 |
| Apr 1, 2025 | Mandel-Brehm Josh | Chief Executive Officer | A | 160,000 | $0.0000 | $0.00 |
| Apr 1, 2025 | Gold Kelly | Chief Financial Officer | A | 80,000 | $0.0000 | $0.00 |
| Apr 1, 2025 | Maricich Yuri | Chief Medical Officer | A | 80,000 | $0.0000 | $0.00 |
| Apr 1, 2025 | Bumcrot David | Chief Scientific Officer | A | 45,000 | $0.0000 | $0.00 |
| Mar 17, 2025 | Stewart Murray | Director | A | 17,787 | $0.0000 | $0.00 |
| Mar 17, 2025 | WILLIAMS DOUGLAS E | Director | A | 17,787 | $0.0000 | $0.00 |
| Oct 15, 2024 | Schwab Andrew J. | Director, 10% Owner | C | 302,770 | – | – |
| Oct 15, 2024 | Schwab Andrew J. | Director, 10% Owner | C | 378,463 | – | – |
| Oct 15, 2024 | Schwab Andrew J. | Director, 10% Owner | C | 1,337,592 | – | – |
| Oct 15, 2024 | Nashat Amir | Director, 10% Owner | C | 24,745 | – | – |
| Oct 15, 2024 | Nashat Amir | Director, 10% Owner | C | 353,718 | – | – |
| Oct 15, 2024 | Nashat Amir | Director, 10% Owner | C | 87,448 | – | – |
| Oct 15, 2024 | Nashat Amir | Director, 10% Owner | C | 1,250,061 | – | – |
| Oct 15, 2024 | Schwab Andrew J. | Director, 10% Owner | P | 909,090 | $11.0000 | $10.00M |
| Oct 15, 2024 | Nashat Amir | Director, 10% Owner | P | 909,090 | $11.0000 | $10.00M |
| Oct 15, 2024 | 5AM Partners VI, LLC | 10% Owner | C | 302,770 | – | – |
| Oct 15, 2024 | 5AM Partners VI, LLC | 10% Owner | C | 378,463 | – | – |