First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Darwin Global Management, Ltd.CIK 0001839209 | 3,057,412 | $456.10M | +29,708 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 1,114,784 | $177.74M | +1,114,784 | NEW |
UBS Group AGCIK 0001610520 | 768,359 | $122.51M | +639,607 | ↑ INC |
RTW INVESTMENTS, LPCIK 0001493215 | 715,332 | $114.05M | – | no_change |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 570,088 | $90.89M | +11,206 | ↑ INC |
Holocene Advisors, LPCIK 0001700574 | 494,495 | $78.84M | +410,428 | ↑ INC |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 357,650 | $57.02M | -25,441 | ↓ DEC |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 304,013 | $48.47M | +70,200 | ↑ INC |
MORGAN STANLEYCIK 0000895421 | 201,409 | $32.11M | +173,396 | ↑ INC |
PERCEPTIVE ADVISORS LLCCIK 0001224962 | 151,979 | $24.23M | -262,260 | ↓ DEC |
Patient Square Capital LPCIK 0001819257 | 116,684 | $18.60M | +116,684 | NEW |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 105,509 | $16.82M | +60,910 | ↑ INC |
MPM BioImpact LLCCIK 0001687078 | 88,045 | $14.04M | +285 | ↑ INC |
Affinity Asset Advisors, LLCCIK 0001773195 | 65,000 | $10.36M | +45,000 | ↑ INC |
FRED ALGER MANAGEMENT, LLCCIK 0000003520 | 62,574 | $9.98M | -16,820 | ↓ DEC |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 52,000 | $8.29M | +49,188 | ↑ INC |
Longaeva Partners L.P.CIK 0002054122 | 33,492 | $5.34M | +33,492 | NEW |
TD ASSET MANAGEMENT INCCIK 0001056053 | 33,410 | $5.33M | +33,410 | NEW |
BNP PARIBAS FINANCIAL MARKETSCIK 0001166588 | 32,525 | $5.19M | +30,077 | ↑ INC |
ADAR1 Capital Management, LLCCIK 0001940272 | 26,880 | $4.29M | -12,959 | ↓ DEC |
Artia Global Partners LPCIK 0001937964 | 24,989 | $3.98M | +7,000 | ↑ INC |
Quadrature Capital LtdCIK 0001651424 | 23,708 | $3.78M | -1,124 | ↓ DEC |
Aquatic Capital Management LLCCIK 0001803916 | 20,294 | $3.24M | +20,253 | ↑ INC |
MANUFACTURERS LIFE INSURANCE COMPANY, THECIK 0000928047 | 19,600 | $3.13M | +19,600 | NEW |
Squarepoint Ops LLCCIK 0001642575 | 16,981 | $2.71M | +16,981 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
Paradigm Biocapital Advisors LPNEW | +1,114,784 | $177.74M |
UBS Group AG↑ INC | +639,607 | $122.51M |
Holocene Advisors, LP↑ INC | +410,428 | $78.84M |
PRICE T ROWE ASSOCIATES INC /MD/NEW | +281,805 | $44.93K |
MORGAN STANLEY↑ INC | +173,396 | $32.11M |
Patient Square Capital LPNEW | +116,684 | $18.60M |
Duquesne Family Office LLCNEW | +106,100 | $16.92K |
DEERFIELD MANAGEMENT COMPANY, L.P.↑ INC | +70,200 | $48.47M |
GOLDMAN SACHS GROUP INC↑ INC | +60,910 | $16.82M |
RENAISSANCE TECHNOLOGIES LLC↑ INC | +49,188 | $8.29M |
| Filer | Δ Shares | Value |
|---|---|---|
PERCEPTIVE ADVISORS LLC↓ DEC | -262,260 | $24.23M |
EVENTIDE ASSET MANAGEMENT, LLC↓ DEC | -25,441 | $57.02M |
JANE STREET GROUP, LLC↓ DEC | -20,096 | $1.95M |
FRED ALGER MANAGEMENT, LLC↓ DEC | -16,820 | $9.98M |
ADAR1 Capital Management, LLC↓ DEC | -12,959 | $4.29M |
AMERIPRISE FINANCIAL INC↓ DEC | -10,454 | $441.17K |
CITADEL ADVISORS LLC↓ DEC | -3,047 | $320.16K |
CITIGROUP INC↓ DEC | -2,136 | $159.00 |
Quadrature Capital Ltd↓ DEC | -1,124 | $3.78M |
SG Americas Securities, LLC↓ DEC | -611 | $342.00 |