| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 9, 2026 | Robertson Scott M. | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | Simson Jake | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | POWELL MICHAEL | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | Mazumdar-Shaw Kiran | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | Haviland Kate | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | Bowden Christopher | Director | A | 19,475 | $0.0000 | $0.00 |
| Jun 9, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 19,475 | $0.0000 | $0.00 |
| May 21, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $0.0000 | $0.00 |
| May 21, 2026 | Hyep Ivan | Chief Financial Officer | S | 9,200 | $20.4221 | $187.88K |
| May 21, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $3.7898 | $34.87K |
| May 18, 2026 | Mazumdar Claire | Chief Executive Officer | M | 15,000 | $0.0000 | $0.00 |
| May 18, 2026 | Mazumdar Claire | Chief Executive Officer | S | 2,978 | $20.3481 | $60.60K |
| May 18, 2026 | Mazumdar Claire | Chief Executive Officer | S | 12,022 | $19.9619 | $239.98K |
| May 18, 2026 | Mazumdar Claire | Chief Executive Officer | M | 15,000 | $3.7898 | $56.85K |
| May 15, 2026 | Cohlhepp Ryan | President and COO | M | 8,000 | $0.0000 | $0.00 |
| May 15, 2026 | Cohlhepp Ryan | President and COO | S | 4,500 | $20.2919 | $91.31K |
| May 15, 2026 | Cohlhepp Ryan | President and COO | S | 8,000 | $20.2919 | $162.34K |
| May 15, 2026 | Cohlhepp Ryan | President and COO | M | 8,000 | $3.7898 | $30.32K |
| May 8, 2026 | Schelman William | Chief Medical Officer | A | 85,000 | $0.0000 | $0.00 |
| Apr 27, 2026 | Raben David | Chief Medical Officer | M | 5,500 | $0.0000 | $0.00 |
| Apr 27, 2026 | Raben David | Chief Medical Officer | S | 5,500 | $22.8782 | $125.83K |
| Apr 27, 2026 | Raben David | Chief Medical Officer | M | 5,500 | $3.7898 | $20.84K |
| Apr 21, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $0.0000 | $0.00 |
| Apr 21, 2026 | Hyep Ivan | Chief Financial Officer | S | 9,200 | $23.0015 | $211.61K |
| Apr 21, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $3.7898 | $34.87K |
| Apr 20, 2026 | Mazumdar Claire | Chief Executive Officer | M | 15,000 | $0.0000 | $0.00 |
| Apr 20, 2026 | Mazumdar Claire | Chief Executive Officer | S | 15,000 | $23.6097 | $354.14K |
| Apr 20, 2026 | Mazumdar Claire | Chief Executive Officer | M | 15,000 | $3.7898 | $56.85K |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 7,080 | $0.0000 | $0.00 |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 7,454 | $0.0000 | $0.00 |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 8,226 | $0.0000 | $0.00 |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 7,080 | $5.4537 | $38.61K |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 7,454 | $3.7898 | $28.25K |
| Apr 16, 2026 | Mazumdar Claire | Chief Executive Officer | M | 8,226 | $4.4369 | $36.50K |
| Apr 15, 2026 | Cohlhepp Ryan | President and COO | M | 8,000 | $0.0000 | $0.00 |
| Apr 15, 2026 | Cohlhepp Ryan | President and COO | S | 4,500 | $23.0073 | $103.53K |
| Apr 15, 2026 | Cohlhepp Ryan | President and COO | S | 8,000 | $23.0073 | $184.06K |
| Apr 15, 2026 | Cohlhepp Ryan | President and COO | M | 8,000 | $3.7898 | $30.32K |
| Mar 25, 2026 | Raben David | Chief Medical Officer | M | 5,500 | $0.0000 | $0.00 |
| Mar 25, 2026 | Raben David | Chief Medical Officer | S | 5,500 | $18.9508 | $104.23K |
| Mar 25, 2026 | Raben David | Chief Medical Officer | M | 5,500 | $3.7898 | $20.84K |
| Mar 23, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $0.0000 | $0.00 |
| Mar 23, 2026 | Hyep Ivan | Chief Financial Officer | S | 9,200 | $18.5161 | $170.35K |
| Mar 23, 2026 | Hyep Ivan | Chief Financial Officer | M | 9,200 | $3.7898 | $34.87K |
| Mar 20, 2026 | Mazumdar Claire | Chief Executive Officer | M | 1,596 | $0.0000 | $0.00 |
| Mar 20, 2026 | Mazumdar Claire | Chief Executive Officer | S | 1,596 | $18.9513 | $30.25K |
| Mar 20, 2026 | Mazumdar Claire | Chief Executive Officer | M | 1,596 | $3.7898 | $6.05K |
| Mar 19, 2026 | Mazumdar Claire | Chief Executive Officer | M | 6,905 | $0.0000 | $0.00 |
| Mar 19, 2026 | Mazumdar Claire | Chief Executive Officer | S | 6,905 | $18.7842 | $129.70K |
| Mar 19, 2026 | Mazumdar Claire | Chief Executive Officer | M | 6,905 | $3.7898 | $26.17K |