First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
Cormorant Asset Management, LPCIK 0001583977 | 17,878,594 | $160.01M | – | no_change |
DEERFIELD MANAGEMENT COMPANY, L.P.CIK 0001009258 | 4,885,446 | $43.72M | – | no_change |
Omega Fund Management, LLCCIK 0001637359 | 3,289,661 | $29.44M | – | no_change |
Alphabet Inc.CIK 0001652044 | 2,823,126 | $25.27M | – | no_change |
EcoR1 Capital, LLCCIK 0001587114 | 2,823,126 | $25.27M | – | no_change |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 2,818,348 | $25.22M | -88,655 | ↓ DEC |
Enavate Sciences GP, LLCCIK 0001953107 | 2,626,946 | $23.51M | – | no_change |
CITADEL ADVISORS LLCCIK 0001423053 | 2,528,762 | $22.63M | -1,562 | ↓ DEC |
Novo Holdings A/SCIK 0001388325 | 2,185,923 | $19.56M | +224,606 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 2,088,297 | $18.69M | +3,460 | ↑ INC |
Laurion Capital Management LPCIK 0001390202 | 1,922,656 | $17.21M | +457,718 | ↑ INC |
ARMISTICE CAPITAL, LLCCIK 0001601086 | 1,328,000 | $11.89M | +328,000 | ↑ INC |
Aisling Capital Management LPCIK 0001766721 | 1,018,018 | $9.11M | +453,393 | ↑ INC |
Paradigm Biocapital Advisors LPCIK 0001855655 | 868,213 | $7.77M | -1,393,536 | ↓ DEC |
Octagon Capital Advisors LPCIK 0001839435 | 719,000 | $6.44M | -324,110 | ↓ DEC |
ROYCE & ASSOCIATES LPCIK 0000906304 | 636,522 | $5.70M | +636,522 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 579,234 | $5.19M | +17,247 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 538,441 | $4.82M | +538,441 | NEW |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 541,181 | $4.70M | -541,181 | ↓ DEC |
Ensign Peak Advisors, IncCIK 0001454984 | 320,874 | $2.87M | +320,874 | NEW |
CHARLES SCHWAB INVESTMENT MANAGEMENT INCCIK 0000884546 | 290,806 | $2.60M | +11,760 | ↑ INC |
Casdin Capital, LLCCIK 0001534261 | 282,312 | $2.53M | – | no_change |
Ikarian Capital, LLCCIK 0001778253 | 270,231 | $2.42M | +50,000 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 265,954 | $2.38M | +24,539 | ↑ INC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 254,329 | $2.28M | +254,329 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
ROYCE & ASSOCIATES LPNEW | +636,522 | $5.70M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +538,441 | $4.82M |
Laurion Capital Management LP↑ INC | +457,718 | $17.21M |
Aisling Capital Management LP↑ INC | +453,393 | $9.11M |
ARMISTICE CAPITAL, LLC↑ INC | +328,000 | $11.89M |
Ensign Peak Advisors, IncNEW | +320,874 | $2.87M |
VANGUARD FIDUCIARY TRUST CONEW | +254,329 | $2.28M |
SCHRODER INVESTMENT MANAGEMENT GROUPNEW | +249,161 | $2.16M |
Granahan Investment Management, LLCNEW | +231,040 | $2.07M |
Novo Holdings A/S↑ INC | +224,606 | $19.56M |
| Filer | Δ Shares | Value |
|---|---|---|
Paradigm Biocapital Advisors LP↓ DEC | -1,393,536 | $7.77M |
EVENTIDE ASSET MANAGEMENT, LLC↓ DEC | -541,181 | $4.70M |
PRICE T ROWE ASSOCIATES INC /MD/↓ DEC | -365,245 | $3.92K |
Octagon Capital Advisors LP↓ DEC | -324,110 | $6.44M |
HighVista Strategies LLC↓ DEC | -151,076 | $699.77K |
WELLINGTON MANAGEMENT GROUP LLP↓ DEC | -88,655 | $25.22M |
TD ASSET MANAGEMENT INC↓ DEC | -59,578 | $515.27K |
UBS Group AG↓ DEC | -42,919 | $451.53K |
MANUFACTURERS LIFE INSURANCE COMPANY, THE↓ DEC | -18,500 | $319.44K |
CITADEL ADVISORS LLC↓ DEC | -1,562 | $22.63M |