First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
5AM Venture Management, LLCCIK 0001799883 | 2,353,304 | $15.16M | – | no_change |
Venrock Adviser, LLCCIK 0001615982 | 1,609,569 | $10.37M | – | no_change |
venBio Partners LLCCIK 0001776382 | 531,337 | $3.42M | -117,170 | ↓ DEC |
FRANKLIN RESOURCES INCCIK 0000038777 | 520,327 | $3.35M | – | no_change |
Revelation Capital Management, LLCCIK 0001801811 | 299,311 | $1.93M | – | no_change |
BlackRock, Inc.CIK 0002012383 | 213,388 | $1.37M | +850 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 207,686 | $1.34M | +207,686 | NEW |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 194,108 | $1.25M | – | no_change |
Propel Bio Management, LLCCIK 0001969764 | 146,369 | $949.82K | +146,369 | NEW |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 123,270 | $793.86K | -93,827 | ↓ DEC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 115,041 | $740.86K | -29,823 | ↓ DEC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 101,695 | $655.45K | +578 | ↑ INC |
Alyeska Investment Group, L.P.CIK 0001453072 | 100,000 | $644.00K | – | no_change |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 80,038 | $515.45K | -36,162 | ↓ DEC |
JANE STREET GROUP, LLCCIK 0001595888 | 39,496 | $254.35K | -1,175 | ↓ DEC |
STATE STREET CORPCIK 0000093751 | 35,824 | $230.71K | – | no_change |
BRIDGEWAY CAPITAL MANAGEMENT, LLCCIK 0001107261 | 35,000 | $225.40K | – | no_change |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 32,810 | $211.30K | +32,810 | NEW |
PANAGORA ASSET MANAGEMENT INCCIK 0000883677 | 30,702 | $197.72K | +30,702 | NEW |
Velan Capital Investment Management LPCIK 0001848809 | 25,000 | $161.00K | +25,000 | NEW |
Simplify Asset Management Inc.CIK 0001846368 | 23,230 | $149.60K | +23,230 | NEW |
Sanctuary Advisors, LLCCIK 0001777271 | 21,581 | $138.98K | +21,581 | NEW |
BAILARD, INC.CIK 0000750641 | 20,700 | $133.31K | +20,700 | NEW |
DIMENSIONAL FUND ADVISORS LPCIK 0000354204 | 20,370 | $131.18K | +20,370 | NEW |
XTX Topco LtdCIK 0001828301 | 20,270 | $130.54K | -27,703 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
VANGUARD CAPITAL MANAGEMENT LLCNEW | +207,686 | $1.34M |
Propel Bio Management, LLCNEW | +146,369 | $949.82K |
VANGUARD FIDUCIARY TRUST CONEW | +32,810 | $211.30K |
PANAGORA ASSET MANAGEMENT INCNEW | +30,702 | $197.72K |
Velan Capital Investment Management LPNEW | +25,000 | $161.00K |
Simplify Asset Management Inc.NEW | +23,230 | $149.60K |
Sanctuary Advisors, LLCNEW | +21,581 | $138.98K |
BAILARD, INC.NEW | +20,700 | $133.31K |
DIMENSIONAL FUND ADVISORS LPNEW | +20,370 | $131.18K |
BlackRock, Inc.↑ INC | +850 | $1.37M |
| Filer | Δ Shares | Value |
|---|---|---|
CITADEL ADVISORS LLC↓ DEC | -782,527 | $102.20K |
venBio Partners LLC↓ DEC | -117,170 | $3.42M |
MILLENNIUM MANAGEMENT LLC↓ DEC | -93,827 | $793.86K |
RENAISSANCE TECHNOLOGIES LLC↓ DEC | -36,162 | $515.45K |
UBS Group AG↓ DEC | -35,346 | $9.83K |
TWO SIGMA INVESTMENTS, LP↓ DEC | -29,823 | $740.86K |
XTX Topco Ltd↓ DEC | -27,703 | $130.54K |
NORTHERN TRUST CORP↓ DEC | -22,756 | $78.62K |
MORGAN STANLEY↓ DEC | -10,695 | $105.47K |
OMERS ADMINISTRATION Corp↓ DEC | -9,700 | $73.42K |