First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
TCG Crossover Management, LLCCIK 0001839948 | 13,011,849 | $26.09M | +13,011,849 | NEW |
venBio Partners LLCCIK 0001776382 | 12,884,638 | $25.83M | +3,184,713 | ↑ INC |
Redmile Group, LLCCIK 0001425738 | 7,964,188 | $15.97M | +4,699,470 | ↑ INC |
Blackstone Inc.CIK 0001393818 | 5,826,544 | $11.71M | +5,826,544 | NEW |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 5,734,620 | $11.50M | +4,311,738 | ↑ INC |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 4,179,736 | $8.38M | +4,179,736 | NEW |
MARSHALL WACE, LLPCIK 0001318757 | 3,757,216 | $7.51M | +3,730,840 | ↑ INC |
Vivo Capital, LLCCIK 0001674712 | 3,184,713 | $6.39M | -849,809 | ↓ DEC |
Almitas Capital LLCCIK 0001596468 | 3,173,834 | $6.36M | +636,943 | ↑ INC |
5AM Venture Management, LLCCIK 0001799883 | 3,057,325 | $6.13M | +3,057,325 | NEW |
ORBIMED ADVISORS LLCCIK 0001055951 | 2,866,256 | $5.75M | +971,794 | ↑ INC |
MILLENNIUM MANAGEMENT LLCCIK 0001273087 | 1,988,559 | $3.99M | -1,316,060 | ↓ DEC |
TWO SIGMA INVESTMENTS, LPCIK 0001179392 | 1,587,833 | $3.18M | +947,628 | ↑ INC |
Squadron Capital Management LLCCIK 0002050709 | 1,460,000 | $2.93M | +1,460,000 | NEW |
SUSQUEHANNA INTERNATIONAL GROUP, LLPCIK 0001446194 | 1,362,707 | $2.73M | +1,178,380 | ↑ INC |
Ensign Peak Advisors, IncCIK 0001454984 | 950,550 | $1.91M | +949,200 | ↑ INC |
UBS Group AGCIK 0001610520 | 914,754 | $1.83M | +48,763 | ↑ INC |
RENAISSANCE TECHNOLOGIES LLCCIK 0001037389 | 732,599 | $1.47M | +309,500 | ↑ INC |
BANK OF AMERICA CORP /DE/CIK 0000070858 | 577,783 | $1.16M | +45,938 | ↑ INC |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 493,437 | $989.76K | +139,741 | ↑ INC |
BlackRock, Inc.CIK 0002012383 | 447,799 | $897.84K | -2,631 | ↓ DEC |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 294,478 | $590.43K | +294,478 | NEW |
STATE STREET CORPCIK 0000093751 | 175,828 | $352.54K | +51,600 | ↑ INC |
GOLDMAN SACHS GROUP INCCIK 0000886982 | 138,593 | $277.88K | +121,331 | ↑ INC |
NORTHERN TRUST CORPCIK 0000073124 | 136,964 | $274.61K | -12,133 | ↓ DEC |
| Filer | Δ Shares | Value |
|---|---|---|
TCG Crossover Management, LLCNEW | +13,011,849 | $26.09M |
Blackstone Inc.NEW | +5,826,544 | $11.71M |
Redmile Group, LLC↑ INC | +4,699,470 | $15.97M |
DRIEHAUS CAPITAL MANAGEMENT LLC↑ INC | +4,311,738 | $11.50M |
VANGUARD CAPITAL MANAGEMENT LLCNEW | +4,179,736 | $8.38M |
MARSHALL WACE, LLP↑ INC | +3,730,840 | $7.51M |
venBio Partners LLC↑ INC | +3,184,713 | $25.83M |
5AM Venture Management, LLCNEW | +3,057,325 | $6.13M |
Squadron Capital Management LLCNEW | +1,460,000 | $2.93M |
SUSQUEHANNA INTERNATIONAL GROUP, LLP↑ INC | +1,178,380 | $2.73M |
| Filer | Δ Shares | Value |
|---|---|---|
MILLENNIUM MANAGEMENT LLC↓ DEC | -1,316,060 | $3.99M |
Vivo Capital, LLC↓ DEC | -849,809 | $6.39M |
ACADIAN ASSET MANAGEMENT LLC↓ DEC | -273,248 | $2.20K |
CITADEL ADVISORS LLC↓ DEC | -133,432 | $74.19K |
JANE STREET GROUP, LLC↓ DEC | -111,360 | $190.68K |
Invesco Ltd.↓ DEC | -62,856 | $22.01K |
Graham Capital Management, L.P.↓ DEC | -59,110 | $75.67K |
GSA CAPITAL PARTNERS LLP↓ DEC | -23,667 | $138.00 |
NORTHERN TRUST CORP↓ DEC | -12,133 | $274.61K |
Callan Family Office, LLC↓ DEC | -5,889 | $44.95K |