| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jul 6, 2026 | Pangali Sanam | Chief Legal Officer | M | 5,000 | $0.0000 | $0.00 |
| Jul 6, 2026 | Pangali Sanam | Chief Legal Officer | S | 5,000 | $28.0000 | $140.00K |
| Jul 6, 2026 | Pangali Sanam | Chief Legal Officer | M | 5,000 | $5.0600 | $25.30K |
| Jun 30, 2026 | AKKARAJU SRINIVAS | Director | A | 15,528 | $0.0000 | $0.00 |
| Jun 30, 2026 | AKKARAJU SRINIVAS | Director | A | 3,553 | $0.0000 | $0.00 |
| Jun 30, 2026 | Machado Patrick | Director | A | 15,528 | $0.0000 | $0.00 |
| Jun 30, 2026 | Machado Patrick | Director | A | 3,553 | $0.0000 | $0.00 |
| Jun 30, 2026 | Srivastava Sapna | Director | A | 15,528 | $0.0000 | $0.00 |
| Jun 30, 2026 | Srivastava Sapna | Director | A | 3,553 | $0.0000 | $0.00 |
| Jun 30, 2026 | Yao Zhengbin | Director | A | 15,528 | $0.0000 | $0.00 |
| Jun 30, 2026 | Yao Zhengbin | Director | A | 3,553 | $0.0000 | $0.00 |
| Jun 30, 2026 | TETRAULT LYNN A. | Director | A | 15,528 | $0.0000 | $0.00 |
| Jun 30, 2026 | TETRAULT LYNN A. | Director | A | 3,553 | $0.0000 | $0.00 |
| May 22, 2026 | Drappa Jorn | Chief Medical Officer | M | 15,535 | $0.0000 | $0.00 |
| May 22, 2026 | Drappa Jorn | Chief Medical Officer | M | 11,317 | $0.0000 | $0.00 |
| May 22, 2026 | Drappa Jorn | Chief Medical Officer | M | 15,535 | $5.0600 | $78.61K |
| May 22, 2026 | Drappa Jorn | Chief Medical Officer | M | 11,317 | $8.8400 | $100.04K |
| Apr 1, 2026 | Foresite Capital Management VI LLC | 10% Owner | J | 680,486 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Capital Management VI LLC | 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Capital Management VI LLC | 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Capital Management VI LLC | 10% Owner | J | 1,176,470 | $0.0000 | $0.00 |
| Apr 1, 2026 | Tananbaum James B. | Director, 10% Owner | J | 680,486 | $0.0000 | $0.00 |
| Apr 1, 2026 | Tananbaum James B. | Director, 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Tananbaum James B. | Director, 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Tananbaum James B. | Director, 10% Owner | J | 1,176,470 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Labs, LLC | 10% Owner | J | 680,486 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Labs, LLC | 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Labs, LLC | 10% Owner | J | 1,123,337 | $0.0000 | $0.00 |
| Apr 1, 2026 | Foresite Labs, LLC | 10% Owner | J | 1,176,470 | $0.0000 | $0.00 |
| Jan 26, 2026 | Drappa Jorn | Chief Medical Officer | A | 221,450 | $0.0000 | $0.00 |
| Jan 26, 2026 | Bradley Mark Christopher | Chief Development Officer | A | 190,225 | $0.0000 | $0.00 |
| Jan 26, 2026 | Goldstein David M | Chief Scientific Officer | A | 216,675 | $0.0000 | $0.00 |
| Jan 26, 2026 | Schroer John R. | Chief Financial Officer | A | 202,225 | $0.0000 | $0.00 |
| Jan 26, 2026 | Babler Martin | President, CEO and Chairman | A | 745,875 | $0.0000 | $0.00 |
| Jan 26, 2026 | Hardiman Roy C. | Chief Business & Strategy Ofcr | A | 190,875 | $0.0000 | $0.00 |
| Jan 26, 2026 | Pangali Sanam | Chief Legal Officer | A | 186,200 | $0.0000 | $0.00 |
| Jan 9, 2026 | AKKARAJU SRINIVAS | Director | P | 588,235 | $17.0000 | $10.00M |
| Jan 8, 2026 | Foresite Capital Management VI LLC | 10% Owner | P | 294,117 | $17.0000 | $5.00M |
| Jan 8, 2026 | Foresite Capital Management VI LLC | 10% Owner | P | 117,647 | $17.0000 | $2.00M |
| Jan 8, 2026 | Foresite Labs, LLC | 10% Owner | P | 294,117 | $17.0000 | $5.00M |
| Jan 8, 2026 | Foresite Labs, LLC | 10% Owner | P | 117,647 | $17.0000 | $2.00M |
| Jan 8, 2026 | Tananbaum James B. | Director, 10% Owner | P | 294,117 | $17.0000 | $5.00M |
| Jan 8, 2026 | Tananbaum James B. | Director, 10% Owner | P | 117,647 | $17.0000 | $2.00M |
| Dec 5, 2025 | AKKARAJU SRINIVAS | Director | P | 51,380 | $10.7300 | $551.31K |
| Dec 5, 2025 | AKKARAJU SRINIVAS | Director | P | 70,028 | $10.0100 | $700.98K |
| Dec 5, 2025 | AKKARAJU SRINIVAS | Director | P | 64,969 | $8.9500 | $581.47K |
| Dec 4, 2025 | AKKARAJU SRINIVAS | Director | P | 66,027 | $8.1800 | $540.10K |
| Dec 3, 2025 | AKKARAJU SRINIVAS | Director | P | 100,000 | $7.7500 | $775.00K |
| Dec 2, 2025 | AKKARAJU SRINIVAS | Director | P | 96,000 | $7.5500 | $724.80K |
| Dec 1, 2025 | AKKARAJU SRINIVAS | Director | P | 86,350 | $7.4600 | $644.17K |