First-hand SEC EDGAR 13F-HR institutional holdings: the top 25 holders ranked by market value, plus the largest adds and trims this quarter. Quarter 2026-03-31.
| Filer | Shares | Market Value | Δ Shares | Change |
|---|---|---|---|---|
MPM BioImpact LLCCIK 0001687078 | 4,835,872 | $86.51M | +4,835,872 | NEW |
EcoR1 Capital, LLCCIK 0001587114 | 4,824,469 | $86.31M | +4,824,469 | NEW |
Blue Owl Capital Holdings LPCIK 0001858703 | 3,161,348 | $56.56M | +3,161,348 | NEW |
WELLINGTON MANAGEMENT GROUP LLPCIK 0000902219 | 2,317,044 | $41.45M | +2,317,044 | NEW |
BlackRock, Inc.CIK 0002012383 | 2,112,127 | $37.79M | +2,112,127 | NEW |
RTW INVESTMENTS, LPCIK 0001493215 | 1,592,043 | $28.48M | +1,592,043 | NEW |
BAKER BROS. ADVISORS LPCIK 0001263508 | 996,351 | $17.82M | +996,351 | NEW |
Octagon Capital Advisors LPCIK 0001839435 | 960,847 | $17.19M | +960,847 | NEW |
Merck & Co., Inc.CIK 0000310158 | 952,844 | $17.05M | +952,844 | NEW |
VANGUARD CAPITAL MANAGEMENT LLCCIK 0002100119 | 833,913 | $14.92M | +833,913 | NEW |
EVENTIDE ASSET MANAGEMENT, LLCCIK 0001442891 | 507,000 | $9.07M | +507,000 | NEW |
GEODE CAPITAL MANAGEMENT, LLCCIK 0001214717 | 491,936 | $8.80M | +491,936 | NEW |
Avidity Partners Management LPCIK 0001791827 | 468,566 | $8.79M | +468,566 | NEW |
STATE STREET CORPCIK 0000093751 | 428,253 | $7.66M | +428,253 | NEW |
a16z Capital Management, L.L.C.CIK 0001540358 | 415,000 | $7.42M | +415,000 | NEW |
FMR LLCCIK 0000315066 | 386,379 | $6.91M | +386,379 | NEW |
UBS Group AGCIK 0001610520 | 353,263 | $6.32M | +353,263 | NEW |
ArrowMark Colorado Holdings LLCCIK 0001483859 | 329,471 | $5.89M | +329,471 | NEW |
Alyeska Investment Group, L.P.CIK 0001453072 | 290,000 | $5.19M | +290,000 | NEW |
CHARLES SCHWAB INVESTMENT MANAGEMENT INCCIK 0000884546 | 162,017 | $2.90M | +162,017 | NEW |
DRIEHAUS CAPITAL MANAGEMENT LLCCIK 0000938206 | 150,000 | $2.68M | +150,000 | NEW |
NORTHERN TRUST CORPCIK 0000073124 | 149,476 | $2.67M | +149,476 | NEW |
VANGUARD FIDUCIARY TRUST COCIK 0000933478 | 127,395 | $2.28M | +127,395 | NEW |
VANGUARD PORTFOLIO MANAGEMENT LLCCIK 0002100121 | 120,322 | $2.15M | +120,322 | NEW |
AMERIPRISE FINANCIAL INCCIK 0000820027 | 102,925 | $1.84M | +102,925 | NEW |
| Filer | Δ Shares | Value |
|---|---|---|
MPM BioImpact LLCNEW | +4,835,872 | $86.51M |
EcoR1 Capital, LLCNEW | +4,824,469 | $86.31M |
Blue Owl Capital Holdings LPNEW | +3,161,348 | $56.56M |
WELLINGTON MANAGEMENT GROUP LLPNEW | +2,317,044 | $41.45M |
T. Rowe Price Investment Management, Inc.NEW | +2,123,812 | $37.99K |
BlackRock, Inc.NEW | +2,112,127 | $37.79M |
RTW INVESTMENTS, LPNEW | +1,592,043 | $28.48M |
PRICE T ROWE ASSOCIATES INC /MD/NEW | +1,564,196 | $27.98K |
BAKER BROS. ADVISORS LPNEW | +996,351 | $17.82M |
Octagon Capital Advisors LPNEW | +960,847 | $17.19M |