| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 17, 2026 | BAUM CHARLES M | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | DiRocco Derek | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | Magovcevic-Liebisch Ivana | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | Palani Santhosh | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | Shacham Sharon | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | TOMSICEK MICHAEL JOHN | Director | A | 20,275 | $0.0000 | $0.00 |
| Jun 17, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 20,275 | $0.0000 | $0.00 |
| May 21, 2026 | Blume-Jensen Peter | President and CEO | F | 13,729 | $1.7900 | $24.57K |
| May 18, 2026 | Blume-Jensen Peter | President and CEO | A | 72,706 | $0.0000 | $0.00 |
| May 18, 2026 | Blume-Jensen Peter | President and CEO | A | 180,095 | $0.0000 | $0.00 |
| May 18, 2026 | Devroe Eric | Chief Operating Officer | A | 72,981 | $0.0000 | $0.00 |
| May 18, 2026 | Gamelin Erick | Chief Development Officer | A | 38,584 | $0.0000 | $0.00 |
| May 18, 2026 | Levy Adam D. | Chief Financial Officer | A | 46,167 | $0.0000 | $0.00 |
| May 18, 2026 | Miller Mary | Chief Legal Officer | A | 49,830 | $0.0000 | $0.00 |
| May 18, 2026 | Mirza Mansoor Raza | Chief Medical Officer | A | 38,817 | $0.0000 | $0.00 |
| May 18, 2026 | Peterson Katharine | Chief Accounting Officer | A | 14,227 | $0.0000 | $0.00 |
| May 18, 2026 | BAUM CHARLES M | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | DiRocco Derek | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | Magovcevic-Liebisch Ivana | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | Palani Santhosh | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | Shacham Sharon | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | TOMSICEK MICHAEL JOHN | Director | A | 9,366 | $0.0000 | $0.00 |
| May 18, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 9,366 | $0.0000 | $0.00 |
| May 14, 2026 | Blume-Jensen Peter | President and CEO | F | 490 | $1.9200 | $940.00 |
| May 14, 2026 | Blume-Jensen Peter | President and CEO | F | 1,253 | $1.9200 | $2.40K |
| May 14, 2026 | Devroe Eric | Chief Operating Officer | F | 613 | $1.9200 | $1.18K |
| May 14, 2026 | Gamelin Erick | Chief Development Officer | F | 404 | $1.9200 | $775.00 |
| May 14, 2026 | Peterson Katharine | Chief Accounting Officer | F | 99 | $1.9200 | $190.00 |
| May 14, 2026 | Miller Mary | Chief Legal Officer | F | 184 | $1.9200 | $353.00 |
| Apr 22, 2026 | RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | A | 3,888,888 | $1.8000 | $7.00M |
| Apr 17, 2026 | Miller Mary | Chief Legal Officer | F | 558 | $1.7800 | $993.00 |
| Mar 1, 2026 | Blume-Jensen Peter | President and CEO | A | 185,495 | $0.0000 | $0.00 |
| Mar 1, 2026 | Blume-Jensen Peter | President and CEO | A | 417,210 | $0.0000 | $0.00 |
| Mar 1, 2026 | Devroe Eric | Chief Operating Officer | A | 186,728 | $0.0000 | $0.00 |
| Mar 1, 2026 | Gamelin Erick | Chief Development Officer | A | 94,946 | $0.0000 | $0.00 |
| Mar 1, 2026 | Levy Adam D. | Chief Financial Officer | A | 132,925 | $0.0000 | $0.00 |
| Mar 1, 2026 | Miller Mary | Chief Legal Officer | A | 129,760 | $0.0000 | $0.00 |
| Mar 1, 2026 | Mirza Mansoor Raza | Chief Medical Officer | A | 174,068 | $0.0000 | $0.00 |
| Mar 1, 2026 | Peterson Katharine | Chief Accounting Officer | A | 31,900 | $0.0000 | $0.00 |
| Feb 21, 2026 | Blume-Jensen Peter | President and CEO | F | 14,265 | $1.5300 | $21.82K |
| Feb 14, 2026 | Blume-Jensen Peter | President and CEO | F | 579 | $1.6300 | $943.00 |
| Feb 14, 2026 | Blume-Jensen Peter | President and CEO | F | 1,302 | $1.6300 | $2.12K |
| Feb 14, 2026 | Devroe Eric | Chief Operating Officer | F | 723 | $1.6300 | $1.18K |
| Feb 14, 2026 | Gamelin Erick | Chief Development Officer | F | 471 | $1.6300 | $767.00 |
| Feb 14, 2026 | Miller Mary | Chief Legal Officer | F | 217 | $1.6300 | $353.00 |
| Feb 14, 2026 | Peterson Katharine | Chief Accounting Officer | F | 116 | $1.6300 | $189.00 |
| Jan 17, 2026 | Miller Mary | Chief Legal Officer | F | 659 | $1.9800 | $1.30K |
| Jan 14, 2026 | Levy Adam D. | Chief Financial Officer | P | 8,832 | $1.6983 | $15.00K |
| Jan 14, 2026 | Blume-Jensen Peter | President and CEO | P | 49,000 | $1.6760 | $82.12K |
| Jan 13, 2026 | Devroe Eric | Chief Operating Officer | P | 10,000 | $1.7218 | $17.22K |