| Date | Insider | Title | Code | Shares | Price | Value |
|---|---|---|---|---|---|---|
| Jun 21, 2026 | Klickstein Lloyd | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 21, 2026 | Peng Katie | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 21, 2026 | Sinclair Andrew | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 21, 2026 | Grissinger Michael | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 21, 2026 | Chodakewitz Jeffrey | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 21, 2026 | DUBIN STEVE | Director | A | 4,200 | $0.0000 | $0.00 |
| Jun 19, 2026 | Schor Chen | President & CEO | A | 55,000 | $0.0000 | $0.00 |
| Jun 19, 2026 | Aftab Blake | Chief Scientific Officer | A | 55,000 | $0.0000 | $0.00 |
| Apr 27, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | J | 250,000 | – | – |
| Apr 27, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | J | 250,000 | – | – |
| Apr 8, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 40,416 | $6.5200 | $263.51K |
| Apr 8, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 32,523 | $6.2900 | $204.57K |
| Apr 7, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 2,400 | $6.3800 | $15.31K |
| Apr 7, 2026 | ORBIMED ADVISORS LLC | 10% Owner | S | 29,319 | $6.5300 | $191.45K |
| Mar 25, 2026 | Aftab Blake | Chief Scientific Officer | A | 72,555 | $0.0000 | $0.00 |
| Mar 25, 2026 | Healey Don | Chief Technology Officer | A | 43,361 | $0.0000 | $0.00 |
| Mar 25, 2026 | Maltzman Julia D. | Chief Medical Officer | A | 72,555 | $0.0000 | $0.00 |
| Mar 25, 2026 | Schor Chen | President & CEO | A | 468,555 | $0.0000 | $0.00 |
| Mar 25, 2026 | Harvey Brian Nicholas | Chief Financial Officer | A | 43,361 | $0.0000 | $0.00 |
| Feb 20, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 74,751 | $7.2700 | $543.44K |
| Feb 19, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 74,268 | $7.2100 | $535.47K |
| Feb 18, 2026 | RA CAPITAL MANAGEMENT, L.P. | 10% Owner | P | 74,577 | $7.0400 | $525.02K |
| Jan 24, 2026 | Harvey Brian Nicholas | Chief Financial Officer | F | 546 | $8.4400 | $4.61K |
| Jan 24, 2026 | Schor Chen | President & CEO | F | 1,755 | $8.4400 | $14.81K |
| Jan 24, 2026 | Healey Don | Chief Technology Officer | F | 535 | $8.4400 | $4.51K |
| Jan 24, 2026 | Aftab Blake | Chief Scientific Officer | F | 535 | $8.4400 | $4.51K |
| Oct 8, 2025 | ORBIMED ADVISORS LLC | 10% Owner | P | 3,500,000 | $1.0000 | $3.50M |
| Oct 8, 2025 | ORBIMED ADVISORS LLC | 10% Owner | P | 1,500,000 | $1.0000 | $1.50M |
| Jun 11, 2025 | Sinclair Andrew | Director | A | 26,400 | $0.0000 | $0.00 |
| Jun 11, 2025 | Sinclair Andrew | Director | A | 5,900 | $0.0000 | $0.00 |
| Jun 11, 2025 | Peng Katie | Director | A | 26,400 | $0.0000 | $0.00 |
| Jun 11, 2025 | Peng Katie | Director | A | 5,900 | $0.0000 | $0.00 |
| Jun 11, 2025 | DUBIN STEVE | Director | A | 26,400 | $0.0000 | $0.00 |
| Jun 11, 2025 | DUBIN STEVE | Director | A | 5,900 | $0.0000 | $0.00 |
| Jun 11, 2025 | Chodakewitz Jeffrey | Director | A | 26,400 | $0.0000 | $0.00 |
| Jun 11, 2025 | Chodakewitz Jeffrey | Director | A | 5,900 | $0.0000 | $0.00 |
| Jun 11, 2025 | Klickstein Lloyd | Director | A | 26,400 | $0.0000 | $0.00 |
| Jun 11, 2025 | Klickstein Lloyd | Director | A | 5,900 | $0.0000 | $0.00 |
| Apr 17, 2025 | Grissinger Michael | Director | A | 70,200 | $0.0000 | $0.00 |
| Jan 31, 2025 | Harvey Brian Nicholas | Chief Financial Officer | A | 324,040 | $0.0000 | $0.00 |
| Jan 31, 2025 | Maltzman Julia D. | Chief Medical Officer | A | 750,000 | $0.0000 | $0.00 |
| Jan 31, 2025 | Healey Don | Chief Technology Officer | A | 275,000 | $0.0000 | $0.00 |
| Jan 31, 2025 | Schor Chen | President & CEO | A | 763,829 | $0.0000 | $0.00 |
| Jan 31, 2025 | Aftab Blake | Chief Scientific Officer | A | 275,000 | $0.0000 | $0.00 |
| Jan 24, 2025 | Harvey Brian Nicholas | Chief Financial Officer | F | 8,752 | $0.9218 | $8.07K |
| Jan 24, 2025 | Aftab Blake | Chief Scientific Officer | F | 6,270 | $0.9218 | $5.78K |
| Jan 24, 2025 | Healey Don | Chief Technology Officer | F | 8,560 | $0.9218 | $7.89K |
| Jan 24, 2025 | Schor Chen | President & CEO | F | 28,101 | $0.9218 | $25.90K |
| Aug 21, 2024 | Jakobovits Aya | Director | A | 26,400 | $0.0000 | $0.00 |
| Aug 21, 2024 | Jakobovits Aya | Director | D | 26,400 | $0.0000 | $0.00 |